Standard Name	IOC3 1
Systematic Name	YFR013W
Feature Type	ORF, Verified
Description	Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication (1, 2, 3)
Name Description	Iswi One Complex 1

Chromosomal Location	ChrVI:169922 to 172285 | ORF Map | GBrowse

	View Computational GO annotations for IOC3
Molecular Function
Manually curated	contributes_to ATPase activity (IDA) contributes_to DNA binding (IDA) contributes_to nucleosome binding (IDA)
Biological Process
Manually curated	chromatin remodeling (IPI)
Cellular Component
Manually curated	Isw1 complex (IPI)

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: decreased haploproficient protein transport: abnormal resistance to caffeine: decreased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: increased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to bleomycin: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	71 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-Western: 2 Co-crystal Structure: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 3 Negative Genetic: 17 Positive Genetic: 10 Synthetic Growth Defect: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:169922 to 172285 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2364 169922..172285 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001909