IOC3/YFR013W Summary Help

Standard Name IOC3 1
Systematic Name YFR013W
Feature Type ORF, Verified
Description Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Iswi One Complex 1
Chromosomal Location
ChrVI:169922 to 172285 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IOC3 GO evidence and references
  View Computational GO annotations for IOC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
72 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 29
  • Affinity Capture-Western: 2
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 3
  • Negative Genetic: 17
  • Positive Genetic: 10
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 787
Molecular Weight (Da) 90,896
Isoelectric Point (pI) 7.94
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:169922 to 172285 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2364 169922..172285 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001909
References cited on this page View Complete Literature Guide for IOC3
1) Vary JC Jr, et al.  (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91
2) Morillon A, et al.  (2003) Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Cell 115(4):425-35
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Yen K, et al.  (2012) Genome-wide nucleosome specificity and directionality of chromatin remodelers. Cell 149(7):1461-73