Standard Name	GCN20
Systematic Name	YFR009W
Feature Type	ORF, Verified
Description	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA (1, 2)
Name Description	General Control Nonderepressible 3

Chromosomal Location	ChrVI:162488 to 164746 | ORF Map | GBrowse

	View Computational GO annotations for GCN20
Molecular Function
Manually curated	ATPase activity (ISS)
Biological Process
Manually curated	regulation of translational elongation (IMP, IPI)
Cellular Component
Manually curated	cytosol (IPI) cytosolic ribosome (IDA)

Regulatory modules	predicted: stressResponse (649, 637, 547, 463, 397, 373)

Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to cycloheximide: decreased resistance to bleomycin: increased resistance to sulfometuron methyl: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased starvation resistance: decreased stress resistance: increased toxin resistance: decreased transposable element transposition: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	199 total interaction(s) for 163 unique genes/features.
Physical Interactions	Affinity Capture-MS: 41 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 2 Co-fractionation: 1 Reconstituted Complex: 1 Two-hybrid: 16
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 97 Phenotypic Enhancement: 8 Phenotypic Suppression: 2 Positive Genetic: 16 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:162488 to 164746 | ORF Map | GBrowse
	This feature contains embedded feature(s): YFR009W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2259 162488..164746 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001905