MSH4/YFL003C Summary

MSH4 BASIC INFORMATION

Standard Name	MSH4
Systematic Name	YFL003C
Feature Type	ORF, Verified
Description	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein (1, 2)
Name Description	MutS Homolog

GO Annotations	All MSH4 GO evidence and references
	View Computational GO annotations for MSH4
Molecular Function
Manually curated	DNA binding (IPI)
Biological Process
Manually curated	reciprocal meiotic recombination (IMP)
Cellular Component
Manually curated	nuclear chromosome (IDA)

Mutant Phenotype	All MSH4 Phenotype details and references
Classical genetics
null	meiotic recombination: decreased spore germination: decreased

Interactions	MSH4 All interactions details and references
	22 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 PCA: 2 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 7 Phenotypic Suppression: 4

Sequence Information

ChrVI:137152 to 134516 | |

Note: this feature is encoded on the Crick strand.

This feature contains embedded feature(s): ARS605

Last Update

Coordinates: 2003-09-26 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2637	137152..134516	2003-09-26	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001891

MSH4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MSH4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSH4]

1)	Ross-Macdonald P and Roeder GS (1994) Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell 79(6):1069-80
2)	Novak JE, et al. (2001) The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Genetics 158(3):1013-25

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