WWM1/YFL010C Summary Help

Standard Name WWM1 1
Systematic Name YFL010C
Feature Type ORF, Verified
Description WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 (1, 2, 3, 4)
Name Description WW domain containing protein interacting with Metacaspase 1
Chromosomal Location
ChrVI:115743 to 115108 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All WWM1 GO evidence and references
  View Computational GO annotations for WWM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
104 total interaction(s) for 99 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • Protein-peptide: 51
  • Reconstituted Complex: 8
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 2
  • Negative Genetic: 22
  • Positive Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 211
Molecular Weight (Da) 22,655
Isoelectric Point (pI) 4.12
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:115743 to 115108 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..636 115743..115108 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001884
References cited on this page View Complete Literature Guide for WWM1
1) Szallies A, et al.  (2002) A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae. FEBS Lett 517(1-3):144-50
2) Uetz P, et al.  (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-7
3) Madeo F, et al.  (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9(4):911-7
4) Stevenson LF, et al.  (2001) A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Proc Natl Acad Sci U S A 98(7):3946-51