Standard Name	EPL1 1
Systematic Name	YFL024C
Feature Type	ORF, Verified
Description	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb (1, 2, 3, 4)
Name Description	Enhancer of Polycomb Like 1

Chromosomal Location	ChrVI:90345 to 87847 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EPL1
Molecular Function
Manually curated	contributes_to histone acetyltransferase activity (IDA)
Biological Process
Manually curated	DNA repair (IDA) histone acetylation (IDA) positive regulation of macroautophagy (IMP) regulation of transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	NuA4 histone acetyltransferase complex (IPI) Piccolo NuA4 histone acetyltransferase complex (IDA)

Classical genetics
conditional	autophagy: decreased
null	inviable
reduction of function	resistance to methyl methanesulfonate: decreased resistance to sirolimus: decreased silencing: decreased vegetative growth: decreased
repressible	cell cycle progression in M phase: arrested
Large-scale survey
null	haploproficient inviable starvation resistance: decreased
overexpression	silencing: abnormal
reduction of function	competitive fitness: increased resistance to methyl methanesulfonate: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	334 total interaction(s) for 195 unique genes/features.
Physical Interactions	Affinity Capture-MS: 64 Affinity Capture-RNA: 2 Affinity Capture-Western: 58 Biochemical Activity: 2 Co-crystal Structure: 12 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 2
Genetic Interactions	Synthetic Growth Defect: 112 Synthetic Lethality: 71 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:90345 to 87847 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2499 90345..87847 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001870