COS4/YFL062W Summary

COS4/YFL062W Summary

Standard Name	COS4
Systematic Name	YFL062W
Feature Type	ORF, Verified
Description	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (1, 2)
Name Description	COnserved Sequence

Chromosomal Location	ChrVI:6426 to 7565 \| ORF Map \| GBrowse

Gene Ontology Annotations All COS4 GO evidence and references

	View Computational GO annotations for COS4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	cytoplasm (IDA) fungal-type vacuole (IDA) fungal-type vacuole membrane (IDA) integral to membrane (ISM) nucleus (IDA)

Mutant phenotypes All COS4 Phenotype evidence and references

Large-scale survey
overexpression	cell cycle progression: abnormal
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All COS4 Interaction evidence and references

	30 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Biochemical Activity: 1 PCA: 25
Genetic Interactions	Synthetic Rescue: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All COS4 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrVI:6426 to 7565 | |

SGD ORF map

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1140	6426..7565	1996-07-31	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000001832

References cited on this page View Complete Literature Guide for COS4

1)	Spode I, et al. (2002) ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. J Mol Biol 319(2):407-20
2)	Despons L, et al. (2006) An evolutionary scenario for one of the largest yeast gene families. Trends Genet 22(1):10-5