GEX2/YKR106W Summary Help

Standard Name GEX2 1
Systematic Name YKR106W
Feature Type ORF, Verified
Description Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication (1, 2)
Name Description Glutathione EXchanger 1
Chromosomal Location
ChrXI:661442 to 663289 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GEX2 GO evidence and references
  View Computational GO annotations for GEX2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Large-scale survey
null
overexpression
Resources
9 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 4
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 615
Molecular Weight (Da) 68,953
Isoelectric Point (pI) 9.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:661442 to 663289 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1848 661442..663289 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001814
References cited on this page View Complete Literature Guide for GEX2
1) Dhaoui M, et al.  (2011) Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis. Mol Biol Cell 22(12):2054-67
2) Katju V, et al.  (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75