MLP1/YKR095W Summary Help

MLP1 BASIC INFORMATION

Standard Name MLP1 1
Systematic Name YKR095W
Alias MPL1
Feature Type ORF, Verified
Description Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs (1, 2, 3, 4, 5)
Name Description Myosin-Like Protein 1
GO Annotations All MLP1 GO evidence and references
    View Computational GO annotations for MLP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MLP1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions MLP1 All interactions details and references
68 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Biochemical Activity: 2
  • Co-localization: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 11
  • Phenotypic Suppression: 14
  • Synthetic Growth Defect: 2
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 3
Sequence Information
ChrXI:619447 to 625074 | ORF Map | GBrowse
Gbrowse
Genetic position: 80.3 cM
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..5628 619447..625074 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001803

MLP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MLP1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
YKL161CNomenclature conflictBoth MLP1/YKR095W and YKL161C have been referred to as MLP1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MLP1]

1) Kolling R, et al.  (1993) A new yeast gene with a myosin-like heptad repeat structure. Mol Gen Genet 237(3):359-69
2) Strambio-de-Castillia C, et al.  (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J Cell Biol 144(5):839-55
3) Hediger F, et al.  (2002) Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. J Struct Biol 140(1-3):79-91
4) Galy V, et al.  (2004) Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116(1):63-73
5) Palancade B, et al.  (2005) Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles. Mol Biol Cell 16(11):5258-68