SRP40/YKR092C Summary Help

Standard Name SRP40 1
Systematic Name YKR092C
Feature Type ORF, Verified
Description Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 (2, 3, 4)
Name Description Serine Rich Protein 1
Chromosomal Location
ChrXI:613885 to 612665 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SRP40 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
176 total interaction(s) for 141 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 31
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 10
  • PCA: 4
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 64
  • Phenotypic Suppression: 1
  • Positive Genetic: 48
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 406
Molecular Weight (Da) 41,015
Isoelectric Point (pI) 4.03
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:613885 to 612665 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1221 613885..612665 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001800
References cited on this page View Complete Literature Guide for SRP40
1) Lalo D, et al.  (1993) Interactions between three common subunits of yeast RNA polymerases I and III. Proc Natl Acad Sci U S A 90(12):5524-8
2) Yang Y, et al.  (2000) Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Mol Biol Cell 11(2):567-77
3) Ikonomova R, et al.  (1997) The Srp40 protein plays a dose-sensitive role in preribosome assembly or transport and depends on its carboxy-terminal domain for proper localization to the yeast nucleoskeleton. DNA Cell Biol 16(10):1161-73
4) Meier UT  (1996) Comparison of the rat nucleolar protein nopp140 with its yeast homolog SRP40. Differential phosphorylation in vertebrates and yeast. J Biol Chem 271(32):19376-84