DAD2/YKR083C Summary Help

DAD2 BASIC INFORMATION

Standard Name DAD2
Systematic Name YKR083C
Alias HSK1
Feature Type ORF, Verified
Description Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis (1, 2, 3, 4)
Name Description Duo1 And Dam1 interacting 5
GO Annotations All DAD2 GO evidence and references
    View Computational GO annotations for DAD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DAD2 Phenotype details and references
Large-scale survey
null
Interactions DAD2 All interactions details and references
53 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-purification: 6
  • Two-hybrid: 23
Genetic Interactions
  • Dosage Rescue: 1
Sequence Information
ChrXI:596464 to 596063 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..402 596464..596063 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001791

DAD2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DAD2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DAD2]

1) Li Y, et al.  (2002) The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev 16(2):183-97
2) Miranda JJ, et al.  (2005) The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol 12(2):138-43
3) Westermann S, et al.  (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17(2):277-90
4) Westermann S, et al.  (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440(7083):565-9
5) Cheeseman IM, et al.  (2001) Implication of a novel multiprotein Dam1p complex in outer kinetochore function. J Cell Biol 155(7):1137-45