OAF3/YKR064W Summary Help

Standard Name OAF3 1
Systematic Name YKR064W
Feature Type ORF, Verified
Description Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description Oleate Activated transcription Factor 1
Chromosomal Location
ChrXI:562547 to 565138 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All OAF3 GO evidence and references
  View Computational GO annotations for OAF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
29 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Co-purification: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 18
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 863
Molecular Weight (Da) 101,824
Isoelectric Point (pI) 6.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:562547 to 565138 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2592 562547..565138 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001772
References cited on this page View Complete Literature Guide for OAF3
1) Smith JJ, et al.  (2007) Transcriptional responses to fatty acid are coordinated by combinatorial control. Mol Syst Biol 3():115
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
5) MacPherson S, et al.  (2006) A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol Mol Biol Rev 70(3):583-604
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76