Standard Name	TIF1 1
Systematic Name	YKR059W
Feature Type	ORF, Verified
Description	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description	Translation Initiation Factor
Gene Product Alias	eIF4A

Chromosomal Location	ChrXI:554987 to 556174 | ORF Map | GBrowse
	Genetic position: 22 cM

	View Computational GO annotations for TIF1
Molecular Function
Manually curated	ATP-dependent RNA helicase activity (IDA, IMP) translation initiation factor activity (IDA, IMP)
Biological Process
Manually curated	translational initiation (IDA, IMP)
Cellular Component
Manually curated	eukaryotic translation initiation factor 4F complex (IGI, ISS) ribosome (TAS)

Classical genetics
null	resistance to St. John's Wort extract: decreased
Large-scale survey
null	cell cycle progression in G1 phase: delayed chronological lifespan: decreased competitive fitness: decreased replicative lifespan: increased resistance to St. John's Wort extract: decreased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to caffeine: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to sirolimus: decreased telomere length: increased viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	163 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 3 Affinity Capture-Western: 6 Biochemical Activity: 1 Co-crystal Structure: 1 PCA: 1 Protein-RNA: 4 Reconstituted Complex: 4 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 9 Negative Genetic: 39 Positive Genetic: 30 Synthetic Growth Defect: 5 Synthetic Lethality: 6 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:554987 to 556174 | ORF Map | GBrowse
	Genetic position: 22 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1188 554987..556174 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001767