SUMMARY PARAGRAPH for RHO4
RHO4 encodes a non-essential small GTPase in the Rho/Rac subfamily of Ras-like GTPases (4). Other S. cerevisiae Rho GTPases are encoded by RHO1, RHO2, RHO3, RHO5, and CDC42 (2). Like other eukaryotic Rho-type GTPases, Rho4p is likely to be involved in the establishment of cell polarity (2). Rho4p regulates interaction between Bnr1p and Hof1p, two proteins implicated in cytoskeletal organization (5). Deletion of RHO4 causes no apparent defect, but null mutations in RHO3 and RHO4 are synthetically lethal (4, 2). The GTPase activity of Rho4p is positively regulated by the GTPase activating protein (GAP) Rgd1p (1).
Note: The sequence first published for RHO4 3 is missing the first 61 codons (6). Experiments using the truncated RHO4 construct may give different results from those using the full-length construct.
2000-06-16 MIDORI (updated with assistance from Daniel R. TerBush)
Last updated: 1999-11-24