Standard Name	DYN1 1
Systematic Name	YKR054C
Alias	DHC1 2 , PAC6
Feature Type	ORF, Verified
Description	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p (1, 2, 3, 4, 5)
Name Description	DYNein 1

Chromosomal Location	ChrXI:547925 to 535647 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 24.6 cM

	View Computational GO annotations for DYN1
Molecular Function
Manually curated	microtubule motor activity (IDA)
Biological Process
Manually curated	establishment of mitotic spindle orientation (IGI, IMP) mitotic sister chromatid segregation (IGI) mitotic spindle elongation (TAS) nuclear migration along microtubule (TAS)
Cellular Component
Manually curated	astral microtubule (IDA) cell cortex (IDA) cytoplasmic dynein complex (TAS) cytoplasmic microtubule (IDA) spindle pole body (IDA)

Classical genetics
null	nuclear position: abnormal spindle morphology: abnormal
reduction of function	nuclear position: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient Fus-Mid-GFP distribution: abnormal resistance to sirolimus: decreased resistance to streptomycin: decreased resistance to paromomycin: decreased resistance to cycloheximide: decreased starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	406 total interaction(s) for 222 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Co-crystal Structure: 2 Co-fractionation: 1 Co-localization: 7 FRET: 1 PCA: 2 Reconstituted Complex: 6 Two-hybrid: 104
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 4 Negative Genetic: 155 Phenotypic Enhancement: 18 Phenotypic Suppression: 8 Positive Genetic: 9 Synthetic Growth Defect: 27 Synthetic Lethality: 51 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:547925 to 535647 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 24.6 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..12279 547925..535647 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001762