SPC34/YKR037C Summary Help

SPC34 BASIC INFORMATION

Standard Name SPC34
Systematic Name YKR037C
Feature Type ORF, Verified
Description Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body (1, 2, 3, 4, 5)
Name Description Spindle Pole Component
GO Annotations All SPC34 GO evidence and references
    View Computational GO annotations for SPC34
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPC34 Phenotype details and references
Large-scale survey
null
overexpression
repressible
Interactions SPC34 All interactions details and references
111 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • Co-fractionation: 2
  • Co-purification: 29
  • Reconstituted Complex: 7
  • Two-hybrid: 30
Genetic Interactions
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 9
Sequence Information
ChrXI:511439 to 510552 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..888 511439..510552 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001745

SPC34 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPC34

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPC34]

1) Wigge PA, et al.  (1998) Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol 141(4):967-77
2) Li Y, et al.  (2002) The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev 16(2):183-97
3) Miranda JJ, et al.  (2005) The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol 12(2):138-43
4) Westermann S, et al.  (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17(2):277-90
5) Westermann S, et al.  (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440(7083):565-9