SET3/YKR029C Summary 
| Standard Name | SET3 |
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| Systematic Name | YKR029C |
| Feature Type | ORF, Verified |
| Description | Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication (1, 2, 3, 4 and see Summary Paragraph) |
| Name Description | SET domain-containing 5 |
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| Note: this feature is encoded on the Crick strand. | |
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| View Computational GO annotations for SET3 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
| 396 total interaction(s) for 208 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
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| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000001737 |
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Set3 is one of two proteins in yeast that, like Drosophila Trithorax, contains both SET and PHD domains (6). Set3p forms a complex called Set3C with Snt1p, Sif2p, cyclophilin Cpr1p, Hos2p, Hos4p, and Hst1p, that includes both NAD-dependent and NAD-independent histone deacetylase activities (7, 2). Set3C represses early/middle sporulation genes, including those encoding key meiotic regulators such as the IME2 protein kinase and the NDT80 transcription factor (1). Hst1p is also present in a complex with transcriptional repressor Sum1p. However, Hst1p is not required for meiotic repression by Set3C, suggesting that Set3C (without Hst1p) and not Hst1p-Sum1p, is the meiotic-specific repressor of early/middle sporulation genes (1).
Homology searches suggest that Set3C is the yeast analog of the mammalian HDAC3/SMRT complex (1).
Last updated: 2005-04-26 
| 1) | Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 |
| 2) | Wang A, et al. (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4 |
| 3) | Krogan NJ, et al. (2003) Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol 23(12):4207-18 |
| 4) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 5) | Nislow C, et al. (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36 |
| 6) | Aasland R, et al. (1995) The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 20(2):56-9 |
| 7) | Arevalo-Rodriguez M and Heitman J (2005) Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Eukaryot Cell 4(1):17-29 |
