Standard Name	SAP190 1
Systematic Name	YKR028W
Feature Type	ORF, Verified
Description	Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication (1, 2)
Name Description	Sit4 Associated Protein 1

Chromosomal Location	ChrXI:494257 to 497358 | ORF Map | GBrowse

	View Computational GO annotations for SAP190
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	dephosphorylation (IMP) G1/S transition of mitotic cell cycle (IGI, IMP, IPI) TOR signaling cascade (IMP) tRNA wobble uridine modification (IGI)
Cellular Component
Manually curated	cytoplasm (IPI)

Classical genetics
null	lipid particle morphology: abnormal metal resistance: increased Snf1p modification: increased resistance to sirolimus: increased resistance to palmitoleate: normal resistance to oleate: decreased resistance to soraphen A: decreased toxin resistance: increased
overexpression	resistance to hygromycin B: decreased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploproficient lipid particle morphology: abnormal metal resistance: increased resistance to oleate: decreased resistance to quinine: increased resistance to nickel sulfate: increased resistance to sirolimus: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to ethanol: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to wortmannin: normal resistance to fenpropimorph: increased sporulation: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-RNA: 2 Affinity Capture-Western: 2
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 62 Positive Genetic: 34 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:494257 to 497358 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3102 494257..497358 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001736