DBP7/YKR024C Summary

DBP7 BASIC INFORMATION

Standard Name	DBP7
Systematic Name	YKR024C
Feature Type	ORF, Verified
Description	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions (1, 2)
Name Description	Dead Box Protein

GO Annotations	All DBP7 GO evidence and references
	View Computational GO annotations for DBP7
Molecular Function
Manually curated	ATP-dependent RNA helicase activity (TAS)
Biological Process
Manually curated	ribosomal large subunit assembly (IMP) rRNA processing (IMP)
Cellular Component
Manually curated	nucleolus (IDA)

Mutant Phenotype	All DBP7 Phenotype details and references
Classical genetics
repressible	vegetative growth: decreased
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased fermentative growth: decreased rate resistance to L-1,4-dithiothreitol: decreased resistance to nickel(2+): increased resistance to amiodarone: decreased resistance to hydroxyurea: increased resistance to doxorubicin: decreased resistance to hygromycin B: decreased toxin resistance: increased vegetative growth: absent viable

Interactions	DBP7 All interactions details and references
	35 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Synthetic Growth Defect: 4 Synthetic Lethality: 4

Sequence Information

ChrXI:487015 to 484787 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2229	487015..484787	2005-12-15	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001732

DBP7 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DBP7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DBP7]

1)	Daugeron MC and Linder P (1998) Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly. RNA 4(5):566-81
2)	Snoek IS and Steensma HY (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403

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