RSC4/YKR008W Summary

RSC4 BASIC INFORMATION

Standard Name	RSC4
Systematic Name	YKR008W
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling (1, 2, 3)
Name Description	Remodel the Structure of Chromatin

GO Annotations	All RSC4 GO evidence and references
	View Computational GO annotations for RSC4
Molecular Function
Manually curated	contributes_to DNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Mutant Phenotype	All RSC4 Phenotype details and references
Classical genetics
conditional	heat sensitivity: increased
repressible	cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
null	inviable
overexpression	resistance to rapamycin: increased
repressible	mitochondrial morphology: abnormal

Interactions	RSC4 All interactions details and references
	128 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 97 Affinity Capture-Western: 8 Co-crystal Structure: 3 Co-purification: 3 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 5 Synthetic Rescue: 6

Sequence Information

ChrXI:451844 to 453721 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1878	451844..453721	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001716

RSC4 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RSC4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RSC4]

1)	Sengupta SM, et al. (2001) The interactions of yeast SWI/SNF and RSC with the nucleosome before and after chromatin remodeling. J Biol Chem 276(16):12636-44
2)	Lorch Y, et al. (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
3)	Neely KE and Workman JL (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29

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