MEH1/YKR007W Summary Help

Standard Name MEH1 1
Systematic Name YKR007W
Alias EGO1 2 , GSE2 3
Feature Type ORF, Verified
Description Component of the EGO and GSE complexes; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification (1, 2, 3)
Name Description Multicopy suppressor of Ers1 Hygromycin B sensitivity 1
Chromosomal Location
ChrXI:451434 to 451988 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MEH1 GO evidence and references
  View Computational GO annotations for MEH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
164 total interaction(s) for 120 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • Biochemical Activity: 2
  • Co-fractionation: 2
  • PCA: 17
  • Reconstituted Complex: 5
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 65
  • Phenotypic Suppression: 26
  • Positive Genetic: 12
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 184
Molecular Weight (Da) 20,242
Isoelectric Point (pI) 4.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:451434 to 451988 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..555 451434..451988 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001715
References cited on this page View Complete Literature Guide for MEH1
1) Gao XD, et al.  (2005) ERS1 encodes a functional homologue of the human lysosomal cystine transporter. FEBS J 272(10):2497-511
2) Dubouloz F, et al.  (2005) The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19(1):15-26
3) Gao M and Kaiser CA  (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-67