Standard Name	OSH6 1
Systematic Name	YKR003W
Feature Type	ORF, Verified
Description	Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	OxySterol binding protein Homolog 1

Chromosomal Location	ChrXI:445381 to 446727 | ORF Map | GBrowse

	View Computational GO annotations for OSH6
Molecular Function
Manually curated	lipid binding (IDA) oxysterol binding (ISS) phosphatidic acid binding (IDA) phosphatidylinositol-3,4-bisphosphate binding (IDA) phosphatidylinositol-3,5-bisphosphate binding (IDA) phosphatidylinositol-4-phosphate binding (IDA) phosphatidylinositol-5-phosphate binding (IDA)
Biological Process
Manually curated	endocytosis (IGI) exocytosis (IGI) maintenance of cell polarity (IGI) sterol homeostasis (IMP) sterol metabolic process (IGI) sterol transport (IGI)
Cellular Component
Manually curated	cortical endoplasmic reticulum (IDA) cytoplasm (IDA) extrinsic to membrane (IDA)

Classical genetics
misexpression	replicative lifespan: increased
null	ergosterol accumulation: increased viable
overexpression	ergosterol accumulation: decreased resistance to nystatin: increased
Large-scale survey
misexpression	resistance to caffeine: decreased
null	competitive fitness: decreased haploinsufficient resistance to ciclopirox olamine: decreased resistance to caffeine: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	30 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 PCA: 7 Reconstituted Complex: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 4 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:445381 to 446727 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1347 445381..446727 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001711