LOS1/YKL205W Summary Help

LOS1 BASIC INFORMATION

Standard Name LOS1
Systematic Name YKL205W
Feature Type ORF, Verified
Description Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm (1, 2, 3, 4)
Name Description Loss Of Suppression 5
GO Annotations All LOS1 GO evidence and references
    View Computational GO annotations for LOS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All LOS1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions LOS1 All interactions details and references
86 total interaction(s) for 64 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Reconstituted Complex: 4
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Rescue: 7
  • Phenotypic Enhancement: 20
  • Phenotypic Suppression: 6
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 7
  • Synthetic Rescue: 4
Sequence Information
ChrXI:50052 to 53354 | ORF Map | GBrowse
Gbrowse
Genetic position: -149.7 cM
Last Update Coordinates: 2004-02-13 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3303 50052..53354 2004-02-13 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001688

LOS1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for LOS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LOS1]

1) Hurt DJ, et al.  (1987) Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing. Mol Cell Biol 7(3):1208-16
2) Hellmuth K, et al.  (1998) Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA. Mol Cell Biol 18(11):6374-86
3) Shen WC, et al.  (1993) The Saccharomyces cerevisiae LOS1 gene involved in pre-tRNA splicing encodes a nuclear protein that behaves as a component of the nuclear matrix. J Biol Chem 268(26):19436-44
4) Murthi A, et al.  (2009) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in S. cerevisiae. Mol Biol Cell ()
5) Hopper AK, et al.  (1980) Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs. Cell 19(3):741-51