YKT6/YKL196C Summary Help

Standard Name YKT6 1
Systematic Name YKL196C
Feature Type ORF, Verified
Description Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus (2, 3, 4, 5)
Chromosomal Location
ChrXI:75534 to 74932 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YKT6 GO evidence and references
  View Computational GO annotations for YKT6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
conditional
null
repressible
Large-scale survey
conditional
null
Resources
192 total interaction(s) for 78 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 36
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 52
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 9
  • FRET: 1
  • PCA: 1
  • Reconstituted Complex: 31
  • Two-hybrid: 14

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 11
  • Negative Genetic: 20
  • Phenotypic Enhancement: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 200
Molecular Weight (Da) 22,707
Isoelectric Point (pI) 5.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:75534 to 74932 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..603 75534..74932 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001679
References cited on this page View Complete Literature Guide for YKT6
1) Sogaard M, et al.  (1994) A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 78(6):937-48
2) McNew JA, et al.  (1997) Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem 272(28):17776-83
3) Lewis MJ and Pelham HR  (2002) A new yeast endosomal SNARE related to mammalian syntaxin 8. Traffic 3(12):922-9
4) Kweon Y, et al.  (2003) Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole. Mol Biol Cell 14(5):1868-81
5) Dietrich LE, et al.  (2004) The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. EMBO J 23(1):45-53