Standard Name	ZRT3
Systematic Name	YKL175W
Feature Type	ORF, Verified
Description	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency (1)

Chromosomal Location	ChrXI:118793 to 120304 | ORF Map | GBrowse

	View Computational GO annotations for ZRT3
Molecular Function
Manually curated	zinc ion transmembrane transporter activity (IMP, ISS)
Biological Process
Manually curated	cellular zinc ion homeostasis (IMP) zinc ion transport (IMP, ISS)
Cellular Component
Manually curated	fungal-type vacuole membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	metal resistance: increased
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to ciclopirox olamine: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	13 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 PCA: 2 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 6 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:118793 to 120304 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1512 118793..120304 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001658