Standard Name	EBP2 1
Systematic Name	YKL172W
Feature Type	ORF, Verified
Description	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering (1, 2, 3, 4)
Name Description	EBNA1-binding protein (homolog) 1

Chromosomal Location	ChrXI:125759 to 127042 | ORF Map | GBrowse

	View Computational GO annotations for EBP2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	nuclear division (IMP) rRNA processing (IMP)
Cellular Component
Manually curated	nuclear periphery (IDA) nucleolus (IDA) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Classical genetics
conditional	mature 25S rRNA accumulation: decreased heat sensitivity: increased nuclear morphology: abnormal 60S ribosomal subunit accumulation: decreased GFP-Rap1 distribution: abnormal resistance to hygromycin B: decreased resistance to paromomycin: decreased silencing: decreased vegetative growth: decreased rate
null	inviable
reduction of function	cell cycle progression: delayed nuclear position: abnormal resistance to nocodazole: decreased
repressible	vegetative growth: arrested
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	167 total interaction(s) for 106 unique genes/features.
Physical Interactions	Affinity Capture-MS: 84 Affinity Capture-RNA: 2 Affinity Capture-Western: 11 Co-fractionation: 1 Co-localization: 1 PCA: 15 Reconstituted Complex: 1 Two-hybrid: 38
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 1 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 2 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:125759 to 127042 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1284 125759..127042 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001655