MCD4/YKL165C Summary Help

Standard Name MCD4 1
Systematic Name YKL165C
Alias ZRG16 2 , SSU21 3 , FSR2 4
Feature Type ORF, Verified
Description Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol (5)
Name Description Morphogenesis Checkpoint Dependent 1
Chromosomal Location
ChrXI:140691 to 137932 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MCD4 GO evidence and references
  View Computational GO annotations for MCD4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
reduction of function
repressible
Resources
23 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • PCA: 6

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 6
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 919
Molecular Weight (Da) 105,692
Isoelectric Point (pI) 6.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:140691 to 137932 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2760 140691..137932 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001648
References cited on this page View Complete Literature Guide for MCD4
1) Mondesert G, et al.  (1997) Identification of genes controlling growth polarity in the budding yeast Saccharomyces cerevisiae: a possible role of N-glycosylation and involvement of the exocyst complex. Genetics 147(2):421-34
2) Yuan DS  (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
3) Packeiser AN, et al.  (1999) A novel vacuolar protein encoded by SSU21 / MCD4 is involved in cell wall integrity in yeast. Yeast 15(14):1485-501
4) Matsumoto K, et al.  (1986) Fluphenazine-resistant Saccharomyces cerevisiae mutants defective in the cell division cycle. J Bacteriol 168(3):1352-7
5) Gaynor EC, et al.  (1999) MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast. Mol Biol Cell 10(3):627-48