Standard Name	ELF1
Systematic Name	YKL160W
Feature Type	ORF, Verified
Description	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression (1, 2)
Name Description	ELongation Factor 2

Chromosomal Location	ChrXI:153269 to 153706 | ORF Map | GBrowse

	View Computational GO annotations for ELF1
Molecular Function
Manually curated	RNA polymerase II core binding (IDA)
Biological Process
Manually curated	regulation of transcription by chromatin organization (IGI, IMP) transcription elongation from RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	nucleus (IDA) transcription elongation factor complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
unspecified	sterol accumulation: decreased
Large-scale survey
null	auxotrophy competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased nutrient utilization: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to caffeine: increased resistance to fenpropimorph: increased resistance to fluconazole: increased resistance to mycophenolic acid: increased resistance to mycophenolic acid: decreased resistance to arsenite(3-): decreased resistance to hydroxyurea: decreased resistance to bleomycin: increased resistance to calcium dichloride: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: decreased starvation resistance: decreased stress resistance: decreased toxin resistance: increased transposable element transposition: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	217 total interaction(s) for 165 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 4 Affinity Capture-Western: 1 Biochemical Activity: 11 PCA: 2 Reconstituted Complex: 8
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 142 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 17 Synthetic Growth Defect: 7 Synthetic Lethality: 10 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:153269 to 153706 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..438 153269..153706 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001643