Standard Name	DBR1 1
Systematic Name	YKL149C
Alias	PRP26 2
Feature Type	ORF, Verified
Description	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition (1)
Name Description	DeBRanching 1

Chromosomal Location	ChrXI:168829 to 167612 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -106.4 cM

	View Computational GO annotations for DBR1
Molecular Function
Manually curated	RNA lariat debranching enzyme activity (IDA, IMP)
Biological Process
Manually curated	pseudohyphal growth (IMP) RNA catabolic process (IDA, IMP) snoRNA metabolic process (IMP) transposition, RNA-mediated (IMP)
Cellular Component
Manually curated	nucleus (IC)

Classical genetics
null	Ptr2p-GFP accumulation: increased
unspecified	pseudohyphal growth: decreased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased dessication resistance: decreased nutrient utilization: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to hydroxyurea: increased resistance to tunicamycin: increased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to acrolein: decreased stress resistance: decreased toxin resistance: decreased transposable element transposition: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	64 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Biochemical Activity: 1 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 28 Phenotypic Enhancement: 4 Phenotypic Suppression: 6 Positive Genetic: 21 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:168829 to 167612 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -106.4 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1218 168829..167612 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001632