Standard Name	SDH1 1, 2 (see Nomenclature conflict Note)
Systematic Name	YKL148C
Feature Type	ORF, Verified
Description	Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; SDH1 has a paralog, YJL045W, that arose from the whole genome duplication (3, 4, 5) Also known as: SDHA 6
Name Description	Succinate DeHydrogenase 2

Chromosomal Location	ChrXI:171129 to 169207 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SDH1
Molecular Function
Manually curated	flavin adenine dinucleotide binding (IDA, IMP) succinate dehydrogenase (ubiquinone) activity (IDA, IGI, IMP)
Biological Process
Manually curated	cellular respiration (IGI, IMP) mitochondrial electron transport, succinate to ubiquinone (IDA) tricarboxylic acid cycle (IC)
Cellular Component
Manually curated	mitochondrial membrane (IDA) mitochondrial respiratory chain complex II (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	aerobic respiration, electron transport chain superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	reactive oxygen species accumulation: decreased reactive oxygen species accumulation: increased acetic acid excretion: increased hyperosmotic stress resistance: decreased petite Sdh5p accumulation: absent Sdh2p accumulation: absent respiratory growth: absent respiratory growth: decreased rate respiratory metabolism: decreased survival rate in stationary phase: decreased survival rate in stationary phase: increased toxin resistance: increased utilization of carbon source: absent
reduction of function	respiratory growth: decreased rate sporulation: absent
Large-scale survey
null	anaerobic growth: decreased competitive fitness: normal haploinsufficient respiratory growth: absent respiratory growth: decreased rate sporulation efficiency: decreased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	cell cycle progression: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	79 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 47 Phenotypic Suppression: 4 Positive Genetic: 8 Synthetic Growth Defect: 5 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:171129 to 169207 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1923 171129..169207 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001631