SDH1/YKL148C Summary

SDH1 BASIC INFORMATION

Standard Name	SDH1 1, 2
Systematic Name	YKL148C
Feature Type	ORF, Verified
Description	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone (3) Also known as: SDHA 4
Name Description	Succinate DeHydrogenase 2

GO Annotations	All SDH1 GO evidence and references
	View Computational GO annotations for SDH1
Molecular Function
Manually curated	FAD binding (IDA, IMP) succinate dehydrogenase (ubiquinone) activity (IDA, IGI, IMP)
Biological Process
Manually curated	cellular respiration (IGI, IMP) mitochondrial electron transport, succinate to ubiquinone (IDA) tricarboxylic acid cycle (IC)
Cellular Component
Manually curated	mitochondrial membrane (IDA) mitochondrial respiratory chain complex II (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Mutant Phenotype	All SDH1 Phenotype details and references
Classical genetics
null	acetic acid excretion: increased petite Sdh5p accumulation: absent Sdh2p accumulation: absent respiratory growth: decreased rate respiratory metabolism: decreased
reduction of function	respiratory growth: decreased rate sporulation: absent
Large-scale survey
null	respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: decreased viable

Interactions	SDH1 All interactions details and references
	13 total interaction(s) for 8 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Reconstituted Complex: 1
Genetic Interactions	Synthetic Growth Defect: 5 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrXI:171134 to 169212 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-13 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1923	171134..169212	2004-02-13	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001631

SDH1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SDH1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
SOR1	Nomenclature conflict	Both SDH1/YKL148C (succinate dehydrogenase) and SOR1/YJR159W (L-iditol 2-dehydrogenase) have been referred to as SDH1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SDH1]

1)	Chapman KB, et al. (1992) SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Gene 118(1):131-6
2)	Ciriacy M (1977) Isolation and characterization of yeast mutants defective in intermediary carbon metabolism and in carbon catabolite derepression. Mol Gen Genet 154(2):213-20
3)	Oyedotun KS and Lemire BD (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279(10):9424-31
4)	Robinson KM, et al. (1991) Isolation and characterization of a Saccharomyces cerevisiae mutant disrupted for the succinate dehydrogenase flavoprotein subunit. J Biol Chem 266(32):21347-50

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