Standard Name	LTV1
Systematic Name	YKL143W
Alias	YKL2 1
Feature Type	ORF, Verified
Description	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature (1, 2, 3)

Chromosomal Location	ChrXI:176781 to 178172 | ORF Map | GBrowse

	View Computational GO annotations for LTV1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) response to osmotic stress (IMP) ribosomal small subunit biogenesis (IMP) ribosomal small subunit export from nucleus (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) colocalizes_with EGO complex (IDA) late endosome membrane (IDA) nucleus (IDA) preribosome, small subunit precursor (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	hyperosmotic stress resistance: decreased nutrient uptake: decreased oxidative stress resistance: decreased resistance to cycloheximide: normal resistance to anisomycin: decreased resistance to neomycin: decreased resistance to paromomycin: decreased vegetative growth: decreased
Large-scale survey
null	budding index: increased cell size: decreased proton accumulation: decreased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased lipid particle morphology: abnormal resistance to sodium arsenite: increased resistance to nickel sulfate: decreased resistance to arsenite(3-): decreased resistance to (S)-lactic acid: decreased resistance to glycolaldehyde: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	148 total interaction(s) for 113 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-crystal Structure: 1 Co-fractionation: 9 Co-localization: 2 Reconstituted Complex: 9 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 29 Phenotypic Suppression: 1 Positive Genetic: 62 Synthetic Growth Defect: 3 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:176781 to 178172 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1392 176781..178172 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001626