MRP8/YKL142W Summary Help

Standard Name MRP8
Systematic Name YKL142W
Alias YKL3 1
Feature Type ORF, Verified
Description Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis (1, 2, 3, 4, 5)
Name Description Mitochondrial Ribosomal Protein
Chromosomal Location
ChrXI:178515 to 179174 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MRP8 GO evidence and references
  View Computational GO annotations for MRP8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
Resources
58 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 26

Genetic Interactions
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 219
Molecular Weight (Da) 25,097
Isoelectric Point (pI) 4.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:178515 to 179174 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..660 178515..179174 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001625
References cited on this page View Complete Literature Guide for MRP8
1) Abraham PR, et al.  (1992) Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Yeast 8(3):227-38
2) Boorsma A, et al.  (2004) Characterization of the transcriptional response to cell wall stress in Saccharomyces cerevisiae. Yeast 21(5):413-27
3) Zhou W, et al.  (2004) Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem 279(31):32262-8
4) Bruckmann A, et al.  (2009) Proteome analysis of aerobically and anaerobically grown Saccharomyces cerevisiae cells. J Proteomics 71(6):662-9
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76