Standard Name	SDH3 1
Systematic Name	YKL141W
Alias	CYB3 , YKL4 2
Feature Type	ORF, Verified
Description	Subunit of succinate dehydrogenase and of TIM22 translocase; functions as \ cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication (3, 4, 5)
Name Description	Succinate DeHydrogenase 1

Chromosomal Location	ChrXI:179667 to 180263 | ORF Map | GBrowse

	View Computational GO annotations for SDH3
Molecular Function
Manually curated	contributes_to succinate dehydrogenase (ubiquinone) activity (IGI)
Biological Process
Manually curated	cellular respiration (IMP) mitochondrial electron transport, succinate to ubiquinone (TAS) protein import into mitochondrial inner membrane (IMP) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial inner membrane protein insertion complex (IDA) mitochondrial respiratory chain complex II (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Pathways	aerobic respiration, electron transport chain superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	petite-negative respiratory growth: decreased rate
Large-scale survey
null	haploinsufficient inviable
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	66 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 7 Co-localization: 1 PCA: 1 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 29 Positive Genetic: 14 Synthetic Growth Defect: 1 Synthetic Lethality: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:179667 to 180263 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..597 179667..180263 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001624