SDH3/YKL141W Summary Help

Standard Name SDH3 1
Systematic Name YKL141W
Alias CYB3 , YKL4 2
Feature Type ORF, Verified
Description Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication (3, 4, 5)
Name Description Succinate DeHydrogenase 1
Chromosomal Location
ChrXI:179667 to 180263 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SDH3 GO evidence and references
  View Computational GO annotations for SDH3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
reduction of function
Resources
69 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Co-localization: 1
  • PCA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 29
  • Positive Genetic: 14
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 198
Molecular Weight (Da) 22,068
Isoelectric Point (pI) 11.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:179667 to 180263 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..597 179667..180263 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001624
References cited on this page View Complete Literature Guide for SDH3
1) Chapman KB, et al.  (1992) SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Gene 118(1):131-6
2) Abraham PR, et al.  (1992) Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Yeast 8(3):227-38
3) Oyedotun KS and Lemire BD  (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279(10):9424-31
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Gebert N, et al.  (2011) Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane. Mol Cell 44(5):811-8