TGL1/YKL140W Summary Help

Standard Name TGL1
Systematic Name YKL140W
Alias YKL5
Feature Type ORF, Verified
Description Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes (1)
Name Description TriGlyceride Lipase
Chromosomal Location
ChrXI:180779 to 182425 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TGL1 GO evidence and references
  View Computational GO annotations for TGL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
49 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • PCA: 9

Genetic Interactions
  • Negative Genetic: 19
  • Phenotypic Enhancement: 2
  • Positive Genetic: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 548
Molecular Weight (Da) 62,978
Isoelectric Point (pI) 6.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:180779 to 182425 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1647 180779..182425 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001623
References cited on this page View Complete Literature Guide for TGL1
1) Koffel R, et al.  (2005) The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis. Mol Cell Biol 25(5):1655-68