CMC1/YKL137W Summary

CMC1 BASIC INFORMATION

Standard Name	CMC1 1
Systematic Name	YKL137W
Feature Type	ORF, Verified
Description	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif (1, 2)
Name Description	Cx9C Mitochondrial protein necessary for full assembly of Cytochrome c oxidase 1

GO Annotations	All CMC1 GO evidence and references
	View Computational GO annotations for CMC1
Molecular Function
Manually curated	copper ion binding (IDA)
Biological Process
Manually curated	mitochondrial respiratory chain complex IV assembly (IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial intermembrane space (IDA)

Mutant Phenotype	All CMC1 Phenotype details and references
Classical genetics
null	cytochrome c oxidase activity: decreased cytochrome c reductase activity: decreased Cox2p accumulation: decreased respiratory growth: decreased rate
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: normal respiratory growth: decreased rate viable

Interactions	CMC1 All interactions details and references
	View additional details at BioGRID
	43 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-fractionation: 1
Genetic Interactions	Negative Genetic: 34 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Lethality: 1

Sequence Information

ChrXI:185962 to 186297 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 2005-12-15

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..336	185962..186297	2005-12-15	2005-12-15

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001620

CMC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CMC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CMC1]

1)	Horn D, et al. (2008) Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis. Mol Cell Biol 28(13):4354-64
2)	Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4

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