CMC1/YKL137W Summary Help

Standard Name CMC1 1
Systematic Name YKL137W
Feature Type ORF, Verified
Description Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif (1, 2)
Name Description Cx9C Mitochondrial protein necessary for full assembly of Cytochrome c oxidase 1
Chromosomal Location
ChrXI:185957 to 186292 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CMC1 GO evidence and references
  View Computational GO annotations for CMC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 71 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
50 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 35
  • Phenotypic Enhancement: 1
  • Positive Genetic: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 111
Molecular Weight (Da) 13,007
Isoelectric Point (pI) 9.3
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:185957 to 186292 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-12-15
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..336 185957..186292 2011-02-03 2005-12-15
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001620
References cited on this page View Complete Literature Guide for CMC1
1) Horn D, et al.  (2008) Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis. Mol Cell Biol 28(13):4354-64
2) Steinmetz LM, et al.  (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4