Standard Name	OCT1 (see Nomenclature conflict Note)
Systematic Name	YKL134C
Feature Type	ORF, Verified
Description	Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis (1, 2, 3)
Name Description	OCTapeptidyl aminopeptidase
Gene Product Alias	mitochondrial intermediate peptidase 2

Chromosomal Location	ChrXI:191442 to 189124 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for OCT1
Molecular Function
Manually curated	metalloendopeptidase activity (IDA, IMP)
Biological Process
Manually curated	cellular iron ion homeostasis (IGI, IMP) protein processing involved in protein targeting to mitochondrion (IMP)
Cellular Component
Manually curated	mitochondrion (IGI, IMP)
High-throughput	mitochondrion (IDA)

Large-scale survey
null	proton accumulation: decreased glycogen accumulation: decreased competitive fitness: decreased heat sensitivity: increased oxidative stress resistance: decreased resistance to sirolimus: decreased resistance to wortmannin: increased resistance to ethanol: decreased resistance to CTBT: decreased resistance to arsenite(3-): decreased resistance to tunicamycin: decreased resistance to elesclomol-Cu: decreased resistance to trichothecene: increased resistance to sorbate: decreased respiratory growth: decreased rate respiratory growth: absent stress resistance: increased utilization of carbon source: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	67 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 49 Positive Genetic: 7 Synthetic Growth Defect: 6 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:191442 to 189124 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2319 191442..189124 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001617