SHE2/YKL130C Summary Help

SHE2 BASIC INFORMATION

Standard Name SHE2 1
Systematic Name YKL130C
Feature Type ORF, Verified
Description RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud (2, 3, 4, 5, 6)
Name Description Swi5p-dependent HO Expression 1
GO Annotations All SHE2 GO evidence and references
    View Computational GO annotations for SHE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SHE2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SHE2 All interactions details and references
107 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 52
  • Affinity Capture-Western: 9
  • Co-crystal Structure: 2
  • PCA: 2
  • Protein-RNA: 6
  • Reconstituted Complex: 4
  • Two-hybrid: 13
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 1
Sequence Information
ChrXI:196027 to 195287 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..741 196027..195287 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001613

SHE2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SHE2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SHE2]

1) Jansen RP, et al.  (1996) Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins. Cell 84(5):687-97
2) Takizawa PA and Vale RD  (2000) The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Proc Natl Acad Sci U S A 97(10):5273-8
3) Long RM, et al.  (2000) She2p is a novel RNA-binding protein that recruits the Myo4p-She3p complex to ASH1 mRNA. EMBO J 19(23):6592-601
4) Bohl F, et al.  (2000) She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p. EMBO J 19(20):5514-24
5) Shepard KA, et al.  (2003) Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis. Proc Natl Acad Sci U S A 100(20):11429-34
6) Estrada P, et al.  (2003) Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol 163(6):1255-66