YPK1/YKL126W Summary 
| Standard Name | YPK1 (see Nomenclature conflict Note) |
|---|---|
| Systematic Name | YKL126W |
| Alias | SLI2 |
| Feature Type | ORF, Verified |
| Description | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8) |
| Name Description | Yeast Protein Kinase |
| Chromosomal Location | |
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| Genetic position: -97.7 cM |
Gene Ontology Annotations All YPK1 GO evidence and references
| View Computational GO annotations for YPK1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Regulatory Role
| Regulatory modules | predicted: stressResponse (595, 541) |
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Mutant phenotypes All YPK1 Phenotype evidence and references
interactions All YPK1 Interaction evidence and references
| 98 total interaction(s) for 75 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All YPK1 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Genetic position: -97.7 cM | |||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000001609 |
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NOMENCLATURE CONFLICT NOTE
| Name | Relevance | Description |
|---|---|---|
| TOK1 | Nomenclature conflict | YPK1 has been used in the literature to refer to both YPK1/YKL126W which encodes a protein kinase and TOK1/YJL093C which encodes a potassium channel. |
| MCK1 | Nomenclature conflict | YPK1 has been used in the literature to refer to both MCK1/YNL307C, which encodes a glycogen synthase kinase 3 and YPK1/YKL126W which encodes a protein kinase. |
References cited on this page View Complete Literature Guide for YPK1
| 1) | Sun Y, et al. (2000) Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol 20(12):4411-9 |
| 2) | Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 |
| 3) | deHart AK, et al. (2002) The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156(2):241-8 |
| 4) | Schmelzle T, et al. (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39 |
| 5) | Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 |
| 6) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 7) | Roelants FM, et al. (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9 |
| 8) | Roelants FM, et al. (2011) Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 108(48):19222-7 |
