RRN3/YKL125W Summary

RRN3 BASIC INFORMATION

Standard Name	RRN3 1
Systematic Name	YKL125W
Feature Type	ORF, Verified
Description	Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA (2, 3)
Name Description	Regulation of RNA polymerase I 1

GO Annotations	All RRN3 GO evidence and references
	View Computational GO annotations for RRN3
Molecular Function
Manually curated	RNA polymerase I transcription factor activity (TAS)
Biological Process
Manually curated	transcription from RNA polymerase I promoter (TAS) transcription of nuclear rRNA large RNA polymerase I transcript (IGI)
Cellular Component
Manually curated	nucleolus (IDA) RNA polymerase I transcription factor complex (TAS)

Mutant Phenotype	All RRN3 Phenotype details and references
Classical genetics
conditional	rRNA species transcribed by RNA polymerase I accumulation: decreased heat sensitivity: increased
Large-scale survey
null	inviable

Interactions	RRN3 All interactions details and references
	21 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 5 Co-purification: 2 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Lethality: 3

Sequence Information

ChrXI:207891 to 209774 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1884	207891..209774	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001608

RRN3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RRN3

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
SYC1	Nomenclature conflict	RRN3/YKL125W and SYC1/YOR179C have both been referred to as SYC1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRN3]

1)	Nogi Y, et al. (1991) An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(16):7026-30
2)	Yamamoto RT, et al. (1996) RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J 15(15):3964-73
3)	Peyroche G, et al. (2000) The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3. EMBO J 19(20):5473-82

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