VPH2/YKL119C Summary Help

VPH2 BASIC INFORMATION

Standard Name VPH2
Systematic Name YKL119C
Alias CLS10 , VMA12
Feature Type ORF, Verified
Description Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) (1, 2, 3, 4)
Name Description Vacuolar pH
GO Annotations All VPH2 GO evidence and references
    View Computational GO annotations for VPH2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All VPH2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions VPH2 All interactions details and references
  View additional details at BioGRID
103 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • PCA: 2
Genetic Interactions
  • Negative Genetic: 64
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 9
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 3
Sequence Information
ChrXI:218861 to 218214 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..648 218861..218214 2005-12-15 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001602

VPH2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for VPH2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPH2]

1) Preston RA, et al.  (1992) Genes required for vacuolar acidity in Saccharomyces cerevisiae. Genetics 131(3):551-8
2) Jackson DD and Stevens TH  (1997) VMA12 encodes a yeast endoplasmic reticulum protein required for vacuolar H+-ATPase assembly. J Biol Chem 272(41):25928-34
3) Forgac M  (1999) Structure and properties of the vacuolar (H+)-ATPases. J Biol Chem 274(19):12951-4
4) Graham LA and Stevens TH  (1999) Assembly of the yeast vacuolar proton-translocating ATPase. J Bioenerg Biomembr 31(1):39-47