SBA1/YKL117W Summary Help

Standard Name SBA1 1
Systematic Name YKL117W
Alias CST18 2
Feature Type ORF, Verified
Description Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress (1, 3, 4, 5, 6)
Name Description increased Sensitivity to Benzoquinone Ansamycins 1
Chromosomal Location
ChrXI:220324 to 220974 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SBA1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 90 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
429 total interaction(s) for 330 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 10
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • PCA: 4
  • Reconstituted Complex: 84
  • Two-hybrid: 86

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 10
  • Positive Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 210

Resources
Expression Summary
histogram
Resources
Length (a.a.) 216
Molecular Weight (Da) 24,082
Isoelectric Point (pI) 4.29
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:220324 to 220974 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..651 220324..220974 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001600
References cited on this page View Complete Literature Guide for SBA1
1) Bohen SP  (1998) Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol 18(6):3330-9
2) Ouspenski II, et al.  (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8
3) Fang Y, et al.  (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34
4) Toogun OA, et al.  (2007) The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A 104(14):5765-70
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Lancaster DL, et al.  (2013) Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae. J Biol Chem 288(2):1266-76