HSL1/YKL101W Summary Help

HSL1 BASIC INFORMATION

Standard Name HSL1
Systematic Name YKL101W
Alias NIK1 , ELM2 1
Feature Type ORF, Verified
Description Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p (2, 3, 4, 5, 6)
Name Description Histone Synthetic Lethal 7
GO Annotations All HSL1 GO evidence and references
    View Computational GO annotations for HSL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All HSL1 Phenotype details and references
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Interactions HSL1 All interactions details and references
204 total interaction(s) for 149 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 17
  • Biochemical Activity: 72
  • Co-localization: 1
  • PCA: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 51
  • Phenotypic Suppression: 13
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 12
  • Synthetic Rescue: 8
Sequence Information
ChrXI:248564 to 253120 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4557 248564..253120 2005-12-15 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001584

HSL1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HSL1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HSL1]

1) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
2) McMillan JN, et al.  (1999) The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol 19(10):6929-39
3) Shulewitz MJ, et al.  (1999) Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7123-37
4) Longtine MS, et al.  (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61
5) Barral Y, et al.  (1999) Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev 13(2):176-87
6) Sakchaisri K, et al.  (2004) Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A 101(12):4124-9
7) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40