HSL1/YKL101W Summary Help

Standard Name HSL1 1
Systematic Name YKL101W
Alias NIK1 , ELM2 2
Feature Type ORF, Verified
Description Nim1p-related protein kinase; regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p (3, 4, 5, 6, 7)
Name Description Histone Synthetic Lethal 1
Chromosomal Location
ChrXI:248920 to 253476 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HSL1 GO evidence and references
  View Computational GO annotations for HSL1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
507 total interaction(s) for 273 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 19
  • Biochemical Activity: 74
  • Co-localization: 1
  • PCA: 9
  • Protein-peptide: 1
  • Reconstituted Complex: 20
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Growth Defect: 26
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 241
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 5
  • Positive Genetic: 26
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 20
  • Synthetic Rescue: 14

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,518
Molecular Weight (Da) 169,606
Isoelectric Point (pI) 9.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:248920 to 253476 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4557 248920..253476 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001584
References cited on this page View Complete Literature Guide for HSL1
1) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40
2) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
3) McMillan JN, et al.  (1999) The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol 19(10):6929-39
4) Shulewitz MJ, et al.  (1999) Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7123-37
5) Longtine MS, et al.  (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61
6) Barral Y, et al.  (1999) Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev 13(2):176-87
7) Sakchaisri K, et al.  (2004) Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A 101(12):4124-9