MIF2/YKL089W Summary Help

MIF2 BASIC INFORMATION

Standard Name MIF2
Systematic Name YKL089W
Feature Type ORF, Verified
Description Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p (1, 2, 3)
Name Description MItotic Fidelity of chromosome transmission
GO Annotations All MIF2 GO evidence and references
    View Computational GO annotations for MIF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MIF2 Phenotype details and references
Large-scale survey
null
Interactions MIF2 All interactions details and references
56 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-crystal Structure: 1
  • Co-localization: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 14
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 2
Sequence Information
ChrXI:273038 to 274687 | ORF Map | GBrowse
Gbrowse
Genetic position: -43 cM
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1650 273038..274687 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001572

MIF2 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MIF2

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
MAS2Nomenclature conflictMIF2 has been used to refer to both MIF2/YKL089W, which encodes a centromere binding protein, and MAS2/YHR024C, which encodes a subunit of mitochondrial processing peptidase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MIF2]

1) Brown MT, et al.  (1993) MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J Cell Biol 123(2):387-403
2) Meluh PB and Koshland D  (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807
3) Westermann S, et al.  (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22