MPE1/YKL059C Summary Help

Standard Name MPE1 1
Systematic Name YKL059C
Feature Type ORF, Verified
Description Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif; relocalizes to the cytosol in response to hypoxia (1, 2)
Name Description Mutant PCF11 Extragenic suppressor 1
Chromosomal Location
ChrXI:329443 to 328118 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MPE1 GO evidence and references
  View Computational GO annotations for MPE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
reduction of function
Resources
142 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 106
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 28
  • Positive Genetic: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 441
Molecular Weight (Da) 49,647
Isoelectric Point (pI) 6.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:329443 to 328118 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1326 329443..328118 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001542
References cited on this page View Complete Literature Guide for MPE1
1) Vo LT, et al.  (2001) Mpe1, a zinc knuckle protein, is an essential component of yeast cleavage and polyadenylation factor required for the cleavage and polyadenylation of mRNA. Mol Cell Biol 21(24):8346-56
2) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30