CSE4/YKL049C Summary Help

CSE4 BASIC INFORMATION

Standard Name CSE4 1
Systematic Name YKL049C
Alias CSL2 2
Feature Type ORF, Verified
Description Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A (1, 3)
Name Description Chromosome SEgregation 1
GO Annotations All CSE4 GO evidence and references
    View Computational GO annotations for CSE4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CSE4 Phenotype details and references
Classical genetics
repressible
Large-scale survey
null
overexpression
Interactions CSE4 All interactions details and references
74 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 15
  • Co-localization: 9
  • Reconstituted Complex: 1
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 7
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 9
  • Synthetic Rescue: 2
Sequence Information
ChrXI:346408 to 345719 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 2003-01-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..690 346408..345719 2005-12-15 2003-01-10
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001532

CSE4 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CSE4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CSE4]

1) Stoler S, et al.  (1995) A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev 9(5):573-86
2) Baker RE, et al.  (1998) Mutations synthetically lethal with cep1 target S. cerevisiae kinetochore components. Genetics 149(1):73-85
3) Meluh PB, et al.  (1998) Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell 94(5):607-13