ELM1/YKL048C Summary Help

ELM1 BASIC INFORMATION

Standard Name ELM1
Systematic Name YKL048C
Alias LDB9
Feature Type ORF, Verified
Description Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring (1, 2, 3, 4, 5 and see Summary Paragraph)
Name Description ELongated Morphology 6
GO Annotations All ELM1 GO evidence and references
    View Computational GO annotations for ELM1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 365 , 293 , 281 )
Mutant Phenotype All ELM1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions ELM1 All interactions details and references
132 total interaction(s) for 108 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 10
  • Co-localization: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 45
  • Phenotypic Suppression: 12
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 29
  • Synthetic Rescue: 6
Sequence Information
ChrXI:348780 to 346858 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1923 348780..346858 2005-12-15 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001531

ELM1 RESOURCES

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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ELM1

SUMMARY PARAGRAPH for ELM1

Elm1p is a serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis (2, 4, 1). Elm1p is required for the normal hyperphosphorylation of the Swe1p kinase during mitosis, and for the proper regulation of a number of other kinases, including Snf1p, Cla4p, and Gin4p (3). Elm1p interacts genetically with Cla4p, Gin4p, and the mitotic cyclins (3).

Elm1p is localized at the bud neck in a septin-dependent fashion from bud emergence until the completion of anaphase, at about the time of cell division (1). Elm1p forms part of the bud neck ring, and is required for the localization of Hsl1p and Cdc12p to the bud neck ring (5).

Strains mutant in Elm1p display ectopic localization of Cdc12p at the bud tip (5), delayed cytokinesis (1), failure to negatively regulate polar bud growth during mitosis, and defects in septin organization (3). Deletion results in constitutive filamentous growth (7); overexpression causes elongated bud formation (8).

Last updated: 2004-04-15

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ELM1]

1) Bouquin N, et al.  (2000) Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae. J Cell Sci 113 ( Pt 8)():1435-45
2) Garrett JM  (1997) The control of morphogenesis in Saccharomyces cerevisiae by Elm1 kinase is responsive to RAS/cAMP pathway activity and tryptophan availability. Mol Microbiol 26(4):809-20
3) Sreenivasan A and Kellogg D  (1999) The elm1 kinase functions in a mitotic signaling network in budding yeast. Mol Cell Biol 19(12):7983-94
4) Koehler CM and Myers AM  (1997) Serine-threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae. FEBS Lett 408(1):109-14
5) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
6) Blacketer MJ, et al.  (1993) Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A. Mol Cell Biol 13(9):5567-81
7) Edgington NP, et al.  (1999) Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28. Mol Cell Biol 19(2):1369-80
8) Moriya H and Isono K  (1999) Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae. Yeast 15(6):481-96