SPC42/YKL042W Summary

SPC42 BASIC INFORMATION

Standard Name	SPC42
Systematic Name	YKL042W
Feature Type	ORF, Verified
Description	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane (1)
Name Description	Spindle Pole Component

GO Annotations	All SPC42 GO evidence and references
	View Computational GO annotations for SPC42
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) spindle pole body duplication in nuclear envelope (IMP)
Cellular Component
Manually curated	central plaque of spindle pole body (IDA) intermediate layer of spindle pole body (IDA)

Mutant Phenotype	All SPC42 Phenotype details and references
Classical genetics
overexpression	budding: abnormal cell cycle progression in G2 phase: abnormal cell size: increased
Large-scale survey
null	inviable
overexpression	inviable

Interactions	SPC42 All interactions details and references
	59 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 5 Biochemical Activity: 9 Co-crystal Structure: 1 Co-purification: 1 FRET: 7 Reconstituted Complex: 2 Two-hybrid: 21
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Synthetic Growth Defect: 4 Synthetic Lethality: 2

Sequence Information

ChrXI:358119 to 359210 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1092	358119..359210	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001525

SPC42 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SPC42

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPC42]

1)	Bullitt E, et al. (1997) The yeast spindle pole body is assembled around a central crystal of Spc42p. Cell 89(7):1077-86

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