TUL1/YKL034W Summary Help

Standard Name TUL1 1
Systematic Name YKL034W
Feature Type ORF, Verified
Description Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1 (1, 2)
Name Description Transmembrane Ubiquitin Ligase 1
Chromosomal Location
ChrXI:371829 to 374105 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TUL1 GO evidence and references
  View Computational GO annotations for TUL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
12 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 758
Molecular Weight (Da) 87,879
Isoelectric Point (pI) 6.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:371829 to 374105 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2277 371829..374105 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001517
References cited on this page View Complete Literature Guide for TUL1
1) Reggiori F and Pelham HR  (2002) A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Nat Cell Biol 4(2):117-23
2) Ryan CJ, et al.  (2012) Hierarchical Modularity and the Evolution of Genetic Interactomes across Species. Mol Cell 46(5):691-704