IXR1/YKL032C Summary Help

IXR1 BASIC INFORMATION

Standard Name IXR1 1 (see Nomenclature conflict Note)
Systematic Name YKL032C
Alias ORD1 2
Feature Type ORF, Verified
Description Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b (1, 2, 3)
Name Description Intrastrand cross (X)-link Recognition 1
GO Annotations All IXR1 GO evidence and references
    View Computational GO annotations for IXR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle (227)
Mutant Phenotype All IXR1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions IXR1 All interactions details and references
  View additional details at BioGRID
117 total interaction(s) for 108 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Two-hybrid: 2
Genetic Interactions
  • Negative Genetic: 81
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 9
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 11
  • Synthetic Rescue: 3
Sequence Information
ChrXI:381501 to 379708 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1794 381501..379708 2005-12-15 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001515

IXR1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for IXR1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SPE1Nomenclature conflictORD1 has been used in the literature to refer to both IXR1/YKL032C, which encodes a DNA binding protein and SPE1/YKL184W, which encodes a ornithine decarboxylase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IXR1]

1) Brown SJ, et al.  (1993) Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin. Science 261(5121):603-5
2) Lambert JR, et al.  (1994) The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 91(15):7345-9
3) Chow CS, et al.  (1994) HMG domain proteins induce sharp bends in cisplatin-modified DNA. Biochemistry 33(50):15124-30