TFA1/YKL028W Summary Help

Standard Name TFA1 1
Systematic Name YKL028W
Feature Type ORF, Verified
Description TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening (1, 2, 3)
Name Description Transcription Factor a, subunit 1 1
Chromosomal Location
ChrXI:385758 to 387206 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TFA1 GO evidence and references
  View Computational GO annotations for TFA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
reduction of function
Resources
78 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 5
  • Co-purification: 12
  • PCA: 3
  • Reconstituted Complex: 9
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 482
Molecular Weight (Da) 54,741
Isoelectric Point (pI) 4.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:385758 to 387206 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1449 385758..387206 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001511
References cited on this page View Complete Literature Guide for TFA1
1) Feaver WJ, et al.  (1994) Yeast TFIIE. Cloning, expression, and homology to vertebrate proteins. J Biol Chem 269(44):27549-53
2) Lee TI and Young RA  (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137
3) Orphanides G, et al.  (1996) The general transcription factors of RNA polymerase II. Genes Dev 10(21):2657-83