HCS1/YKL017C Summary Help

Standard Name HCS1 1
Systematic Name YKL017C
Alias DIP1
Feature Type ORF, Verified
Description Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities (2, 3, 4)
Name Description dna HeliCaSe 3
Chromosomal Location
ChrXI:407241 to 405190 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HCS1 GO evidence and references
  View Computational GO annotations for HCS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Large-scale survey
null
Resources
9 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 683
Molecular Weight (Da) 78,272
Isoelectric Point (pI) 7.56
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:407241 to 405190 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2052 407241..405190 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001500
References cited on this page View Complete Literature Guide for HCS1
1) Shiratori A, et al.  (1999) Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis. Yeast 15(3):219-53
2) Biswas SB, et al.  (1997) Purification and characterization of DNA polymerase alpha-associated replication protein A-dependent yeast DNA helicase A. Biochemistry 36(43):13270-6
3) Biswas EE, et al.  (1997) Yeast DNA helicase A: cloning, expression, purification, and enzymatic characterization. Biochemistry 36(43):13277-84
4) Biswas EE, et al.  (1993) DNA helicase associated with DNA polymerase alpha: isolation by a modified immunoaffinity chromatography. Biochemistry 32(49):13393-8